68Ga-PSMA Uptake in Neurofibromas Demonstrated on PET/CT in a Patient With Neurofibromatosis Type 1

Clin Nucl Med. 2017 Oct;42(10):776-778. doi: 10.1097/RLU.0000000000001777.

Abstract

We present a case of Ga-PSMA PET/CT imaging of PSMA expression in neurofibromas in a patient with neurofibromatosis type 1 (or von Recklinghausen disease). PSMA uptake has previously been demonstrated in schwannomas both with PET and histological staining. The presented images confirm that PSMA expression in cutaneous neurofibromas can be well imaged with PET, with uptake mostly at relatively low levels. Interestingly, some lesions demonstrated significantly higher PSMA expression, although the clinical significance of these differences remains to be determined. The images raise the possibility of a potential role for Ga-PSMA PET/CT in neurofibromatosis type 1 monitoring.

Publication types

  • Case Reports

MeSH terms

  • Biological Transport
  • Edetic Acid / analogs & derivatives*
  • Edetic Acid / metabolism
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Male
  • Middle Aged
  • Neurofibromatosis 1 / diagnostic imaging*
  • Neurofibromatosis 1 / metabolism*
  • Oligopeptides / metabolism*
  • Positron Emission Tomography Computed Tomography*

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • gallium 68 PSMA-11
  • Edetic Acid