Sex cord stromal tumours of the ovary, experience at Shifa International Hospital Islamabad

J Pak Med Assoc. 2017 Jul;67(7):1107-1108.

Abstract

This descriptive study was carried out at Pathology Department, Shifa International Hospital from 2007 to 2016; all sex cord stromal tumours diagnosed during this time period were included. Epithelial, germ cell and metastatic tumours were excluded from the study. A total of 1254 Ovarian tumours were brought to Shifa of which47 (4%) were labeled as sex cord stromal tumours. Of these 36( 76 %)were granulosa cell tumour (adult33, juvenile3), 7 were labeled as sertoli leydig cell tumours (15%), 3 as thecoma/ fibroma group (7%)and only one case was labeled as microcystic stromal tumour of the ovary (2%). Overall age range for sex cord stromal tumours was 42 (12-71). Immunohistochemistry was done in 41 out of 47 cases. Sex cord stromal tumours of the ovary are rare tumours comprising 4% of the total. Adult Granulosa cell tumour is the commonest tumour seen in our study.

Keywords: Sex cord, Tumours, Ovary..

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism
  • Calbindin 2 / metabolism
  • Child
  • Female
  • Granulosa Cell Tumor / epidemiology*
  • Granulosa Cell Tumor / metabolism
  • Humans
  • Inhibins / metabolism
  • Keratins / metabolism
  • Middle Aged
  • Ovarian Neoplasms / epidemiology*
  • Ovarian Neoplasms / metabolism
  • Pakistan / epidemiology
  • Sertoli-Leydig Cell Tumor / epidemiology*
  • Sertoli-Leydig Cell Tumor / metabolism
  • Sex Cord-Gonadal Stromal Tumors / epidemiology
  • Sex Cord-Gonadal Stromal Tumors / metabolism
  • Thecoma / epidemiology*
  • Thecoma / metabolism
  • Young Adult

Substances

  • Biomarkers, Tumor
  • CALB2 protein, human
  • Calbindin 2
  • Inhibins
  • Keratins