Abstract
This cohort study of patients with Li-Fraumeni syndrome assesses the diagnostic yield and false-positive rate of an annual surveillance program including whole-body magnetic resonance imaging in patients identified as carriers of TP53 gene mutations.
MeSH terms
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Adult
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Aged
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False Positive Reactions
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Female
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Germ-Line Mutation*
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Humans
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Li-Fraumeni Syndrome / diagnostic imaging*
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Li-Fraumeni Syndrome / genetics
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Patient Reported Outcome Measures
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Population Surveillance
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Prognosis
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Tumor Suppressor Protein p53 / genetics*
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Whole Body Imaging
Substances
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TP53 protein, human
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Tumor Suppressor Protein p53