Surveillance of Dutch Patients With Li-Fraumeni Syndrome: The LiFe-Guard Study

JAMA Oncol. 2017 Dec 1;3(12):1733-1734. doi: 10.1001/jamaoncol.2017.1346.

Abstract

This cohort study of patients with Li-Fraumeni syndrome assesses the diagnostic yield and false-positive rate of an annual surveillance program including whole-body magnetic resonance imaging in patients identified as carriers of TP53 gene mutations.

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • False Positive Reactions
  • Female
  • Germ-Line Mutation*
  • Humans
  • Li-Fraumeni Syndrome / diagnostic imaging*
  • Li-Fraumeni Syndrome / genetics
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Patient Reported Outcome Measures
  • Population Surveillance
  • Prognosis
  • Tumor Suppressor Protein p53 / genetics*
  • Whole Body Imaging

Substances

  • TP53 protein, human
  • Tumor Suppressor Protein p53