Abstract
A booster dose of hepatitis B vaccine was given to 143 children in whom hepatitis B had not developed 1 year after initial vaccination. Over the next six years the incidence of hepatitis B in this group was 1.5% per year compared with 11.5% per year in a similar group of unvaccinated children. In the first 4 years the protective efficacy of the vaccine was 100%, but during the 5th and 6th years it fell to 67%. For maximum protection a second booster is needed, 5 years after the first.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carrier State / prevention & control
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Evaluation Studies as Topic
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Female
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Follow-Up Studies
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Hepatitis B / epidemiology
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Hepatitis B / immunology
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Hepatitis B / prevention & control*
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Hepatitis B Antibodies / analysis
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Hepatitis B Vaccines
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Humans
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Immunization, Secondary*
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Infant
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Male
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Senegal
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Time Factors
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Viral Hepatitis Vaccines / administration & dosage*
Substances
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Hepatitis B Antibodies
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Hepatitis B Vaccines
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Viral Hepatitis Vaccines