Restriction-fragment-length polymorphisms in the A-I-C-III gene complex occurring in a family with hypoalphalipoproteinemia

Atherosclerosis. 1986 Oct;62(1):81-7. doi: 10.1016/0021-9150(86)90022-5.

Abstract

Two restriction-fragment-length polymorphisms in the apolipoprotein A-I-C-III gene complex were defined by digestion with PstI and SacI in a family with hypoalphalipoproteinemia. These polymorphisms established a PstI + /SacI - haplotype which may constitute a linkage marker for this condition within the family.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Alleles
  • Apolipoprotein A-I
  • Apolipoprotein C-III
  • Apolipoproteins A / genetics*
  • Apolipoproteins C / genetics*
  • Child
  • Female
  • Genes*
  • Heterozygote
  • Humans
  • Hypolipoproteinemias / blood
  • Hypolipoproteinemias / genetics*
  • Lipoproteins, HDL / blood*
  • Lipoproteins, HDL / genetics
  • Male
  • Middle Aged
  • Pedigree
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*
  • Reference Values

Substances

  • Apolipoprotein A-I
  • Apolipoprotein C-III
  • Apolipoproteins A
  • Apolipoproteins C
  • Lipoproteins, HDL