The HLA DRB1*03:01 allele is associated with NMO regardless of the NMO-IgG status in Brazilian patients from Rio de Janeiro

J Neuroimmunol. 2017 Sep 15:310:1-7. doi: 10.1016/j.jneuroim.2017.05.018. Epub 2017 May 31.

Abstract

The aim of this study was to analyze the HLA class II alleles in neuromyelitis optica (NMO) and MS patients from Rio de Janeiro to clarify whether the pattern of genetic predisposition in NMO is different from the one seen in MS or whether it is possible to determine specific alleles of susceptibility or resistance. The DR3 haplotype was over represented in NMO while the DR15 was over represented in MS. The HLA-DRB1*03:01 allele was associated with NMO regardless the NMO-IgG status but did not influence the long term disability. The comparison of the allele and haplotype frequencies significantly discriminated patients with NMO vs. MS.

Keywords: HLA DR-DQ; Multiple sclerosis; Neuromyelitis optica.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brazil
  • Case-Control Studies
  • Child
  • DNA Mutational Analysis
  • Female
  • Genotype
  • HLA-DQ alpha-Chains / genetics
  • HLA-DQ beta-Chains / genetics
  • HLA-DQ beta-Chains / metabolism
  • HLA-DRB1 Chains / genetics*
  • Humans
  • Immunoglobulin G / metabolism*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis / diagnostic imaging
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology*
  • Neuromyelitis Optica / diagnostic imaging
  • Neuromyelitis Optica / genetics*
  • Neuromyelitis Optica / immunology*
  • Phenotype
  • Severity of Illness Index
  • Young Adult

Substances

  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • HLA-DQA1 antigen
  • HLA-DQB1 antigen
  • HLA-DRB1 Chains
  • HLA-DRB1*03:01 antigen
  • Immunoglobulin G