Satellite Transcripts Locally Promote Centromere Formation

Carlos Perea-Resa; Michael D Blower

doi:10.1016/j.devcel.2017.07.017

Satellite Transcripts Locally Promote Centromere Formation

Dev Cell. 2017 Aug 7;42(3):201-202. doi: 10.1016/j.devcel.2017.07.017.

Authors

Carlos Perea-Resa¹, Michael D Blower²

Affiliations

¹ Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
² Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 28787584
DOI: 10.1016/j.devcel.2017.07.017

Abstract

Centromeric transcription is a common eukaryotic centromere feature, yet it is unclear how transcription is linked to underlying repetitive satellite sequences. In this issue of Developmental Cell, McNulty et al. (2017) show for human centromeres that all α-satellite sequences are transcribed into chromatin-bound RNAs and are required for centromere assembly.

Publication types

Comment

MeSH terms

Centromere*
Chromatin*
DNA, Satellite
Humans
Repetitive Sequences, Nucleic Acid

Substances

Chromatin
DNA, Satellite

Grants and funding

R01 GM122893/GM/NIGMS NIH HHS/United States