Midkine and Melanoma Metastasis: A Malevolent Mix

Sinem Karaman; Kari Alitalo

doi:10.1016/j.devcel.2017.07.015

Midkine and Melanoma Metastasis: A Malevolent Mix

Dev Cell. 2017 Aug 7;42(3):205-207. doi: 10.1016/j.devcel.2017.07.015.

Authors

Sinem Karaman¹, Kari Alitalo²

Affiliations

¹ Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
² Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. Electronic address: [email protected].

PMID: 28787586
DOI: 10.1016/j.devcel.2017.07.015

Abstract

Using an in vivo reporter for lymphangiogenesis, a recent study in Nature from Olmeda et al. (2017) describes a new subset of melanomas that induce systemic pre-conditioning of distant organs for formation of tumor metastatic niches, and identifies the responsible factor as the pleiotropic cytokine midkine.

Publication types

Comment

MeSH terms

Cytokines
Humans
Lymphangiogenesis
Lymphatic Metastasis*
Melanoma
Midkine
Neoplasm Metastasis
Skin Neoplasms*

Substances

Cytokines
Midkine