Immediate and delayed hypersensitivity reactions may occur after the first or many exposures to tocilizumab, and they have varying presentations. Here, we describe a Wolf's isotopic response that manifested in a patient as erythema on the same site of a previous healed herpes zoster infection. This phenomenon has rarely been reported in the literature.
Keywords: TNF-α inhibitor; Wolf's isotopic response; hypersensitivity reaction; rash; rheumatoid arthritis; tocilizumab.
© 2017 The Australasian College of Dermatologists.