Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant

Yonghui Liu; Youzhi Wang; Fan Yu; Zhenqing Zhang; Zhimou Yang; Wenpeng Zhang; Peng George Wang; Wei Zhao

doi:10.1039/c7cc04386d

Potentiating the immune response of MUC1-based antitumor vaccines using a peptide-based nanovector as a promising vaccine adjuvant

Chem Commun (Camb). 2017 Aug 22;53(68):9486-9489. doi: 10.1039/c7cc04386d.

Authors

Yonghui Liu¹, Youzhi Wang, Fan Yu, Zhenqing Zhang, Zhimou Yang, Wenpeng Zhang, Peng George Wang, Wei Zhao

Affiliation

¹ State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300353, P. R. China. [email protected].

PMID: 28799590
DOI: 10.1039/c7cc04386d

Abstract

We utilize the supramolecular self-assembling peptide of Nap-G^DF^DF^DY^DK to construct chemically programmed, self-assembling and self-adjuvant MUC1-based antitumor vaccines. The vaccines, with antigen and adjuvant conjugation through covalent bonds, elicited both humoral and cellular immune responses.

MeSH terms

Adjuvants, Immunologic* / chemistry
Cancer Vaccines / chemistry
Cancer Vaccines / immunology*
Humans
Mucin-1 / chemistry
Mucin-1 / immunology*
Nanofibers / chemistry*
Oligopeptides / chemical synthesis
Oligopeptides / chemistry
Oligopeptides / immunology*

Substances

Adjuvants, Immunologic
Cancer Vaccines
Mucin-1
Oligopeptides