Chronic Urticaria Patient Perspective (CUPP): The First Validated Tool for Assessing Quality of Life in Clinical Practice

Ilaria Baiardini; Fulvio Braido; Giorgia Molinengo; Marco Caminati; MariaTeresa Costantino; Antonio Cristaudo; Mariangiola Crivellaro; Silvia Mariel Ferrucci; Rosella Gallo; Veronica Giorgis; Agostina Legori; Barbara Loera; Irene Martignago; Angelo Valerio Marzano; Aldo Morrone; Roberta Parente; Aurora Parodi; Anna Parolo; Silvia Peveri; Paolo Pigatto; Anna Radice; Erminia Ridolo; Giovanni Rolla; Chiara Roncallo; Oliviero Rossi; Eleonora Savi; Gianenrico Senna; Massimo Triggiani; Giorgio Walter Canonica

doi:10.1016/j.jaip.2017.06.023

Chronic Urticaria Patient Perspective (CUPP): The First Validated Tool for Assessing Quality of Life in Clinical Practice

J Allergy Clin Immunol Pract. 2018 Jan-Feb;6(1):208-218. doi: 10.1016/j.jaip.2017.06.023. Epub 2017 Aug 9.

Authors

Ilaria Baiardini¹, Fulvio Braido², Giorgia Molinengo³, Marco Caminati⁴, MariaTeresa Costantino⁵, Antonio Cristaudo⁶, Mariangiola Crivellaro⁷, Silvia Mariel Ferrucci⁸, Rosella Gallo⁹, Veronica Giorgis¹⁰, Agostina Legori¹¹, Barbara Loera³, Irene Martignago¹², Angelo Valerio Marzano⁸, Aldo Morrone⁶, Roberta Parente¹³, Aurora Parodi⁹, Anna Parolo⁷, Silvia Peveri¹⁴, Paolo Pigatto¹¹, Anna Radice¹⁵, Erminia Ridolo¹², Giovanni Rolla¹⁰, Chiara Roncallo⁵, Oliviero Rossi¹⁵, Eleonora Savi¹⁴, Gianenrico Senna⁴, Massimo Triggiani¹³, Giorgio Walter Canonica¹⁶

Affiliations

¹ Allergy & Respiratory Diseases, Department of Internal Medicine, Genoa University, Genoa, Italy. Electronic address: [email protected].
² Allergy & Respiratory Diseases, Department of Internal Medicine, Genoa University, Genoa, Italy.
³ Department of Psychology, University of Turin, Turin, Italy.
⁴ Allergy Unit and Asthma Center, Verona University and General Hospital, Verona, Italy.
⁵ Struttura Dipartimentale Centro Day Hospital, Allergologia ed Immunologia Clinica, Azienda Socio Sanitaria Territoriale di Mantova, Mantova, Italy.
⁶ IFO, Dermatological Institute S. Gallicano, IRCCS, Rome, Italy.
⁷ Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
⁸ U.O. Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.
⁹ IRCCS, AOU San Martino, IST, Genoa, Italy; Department of Health Sciences, University of Genoa, Genoa, Italy.
¹⁰ Department of Medical Sciences, Allergy and Clinical Immunology, University of Torino & AO Mauriziano "Umberto I", Turin, Italy.
¹¹ Clinical Dermatology, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
¹² Clinical and Experimental Medicine, University of Parma, Parma, Italy.
¹³ Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
¹⁴ UOsD di Allergologia, Ospedale G da Saliceto, Piacenza, Italy.
¹⁵ Allergy Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy.
¹⁶ Personalized Medicine Clinic: Asthma & Allergy-Humanitas Clinical and Research Center, Department of Biomedical Science, Humanitas University, Rozzano, Milan, Italy.

PMID: 28803183
DOI: 10.1016/j.jaip.2017.06.023

Abstract

Background: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice.

Objective: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice.

Methods: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires. The psychometric properties of the CUPP were then tested on a sample of patients enrolled in 13 Italian centers.

Results: The study population in the validation phase comprised 152 patients. The 10-item version of the CUPP showed satisfactory internal consistency (Cronbach's alpha values of 0.76 at visit 1 and 0.90 at visit 2), good criteria, and discriminative and convergent validity. Reliability was assessed in 34 patients with no changes in health (Global Rating Scale = 0 at visit 2) and was satisfactory (CCC [concordance correlation coefficient] = 0.9). Changes in CUPP scores were significantly associated with changes in Urticaria Activity Score (UAS)-Hive count (r = 0.36, P < .001), UAS-Itch severity (r = 0.48, P < .001), and UAS-Total score (r = 0.342, P < .001), all of which indicated good responsiveness. The minimal important difference was 1.5.

Conclusions: CUPP is a simple 10-question tool with good psychometric properties that provides a valid, reliable, and standardized measurement of HRQoL in patients with CU.

Keywords: Assessment; Chronic urticaria; Clinical practice; Quality of life; Routine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Chronic Disease
Female
Humans
Male
Middle Aged
Patient Preference / psychology*
Perception
Psychometrics / methods*
Quality of Life
Reproducibility of Results
Retrospective Studies
Surveys and Questionnaires*
Urticaria / diagnosis*
Urticaria / psychology
Young Adult