Introduction: The phenomenon of graft-versus-host disease, a solid organ transplant recipient, is a rare development with a very poor prognosis.
Case presentation: A 40-year-old woman with type 1 diabetes developed cutaneous graft-versus-host disease following second pancreas transplantation.
Conclusion: The development of a nonspecific rash in the early posttransplant period following a pancreas transplant warrants suspicion for graft-versus-host disease.