Nanoscale Metal-Organic Layers for Deeply Penetrating X-ray-Induced Photodynamic Therapy

Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12102-12106. doi: 10.1002/anie.201704828. Epub 2017 Aug 25.

Abstract

We report the rational design of metal-organic layers (MOLs) that are built from [Hf6 O4 (OH)4 (HCO2 )6 ] secondary building units (SBUs) and Ir[bpy(ppy)2 ]+ - or [Ru(bpy)3 ]2+ -derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy=2,2'-bipyridine, ppy=2-phenylpyridine) and their applications in X-ray-induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy)2 ]+ or [Ru(bpy)3 ]2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X-rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X-PDT to afford superb anticancer efficacy.

Keywords: X-ray; cancer treatment; metal-organic layers; nanoscale materials; photodynamic therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / therapeutic use
  • Colonic Neoplasms / drug therapy
  • Fourier Analysis
  • Metal-Organic Frameworks / chemistry*
  • Mice
  • Microscopy, Atomic Force
  • Microscopy, Electron, Transmission
  • Nanotechnology*
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / therapeutic use
  • Powder Diffraction
  • Reactive Oxygen Species / chemistry
  • Ruthenium Compounds / chemistry
  • X-Rays
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Metal-Organic Frameworks
  • Photosensitizing Agents
  • Reactive Oxygen Species
  • Ruthenium Compounds