Objective: Assessment of tumor response to chemotherapy is essential in managing malignant pediatric bone tumors prior to resection.
Subjects and methods: Pre-chemotherapy and post-chemotherapy osteosarcoma and Ewing sarcoma cases (n=18) were analyzed with apparent diffusion coefficient (ADC) values measured by two readers.
Results: Treated tumors demonstrated significantly greater ADC values compared to untreated tumors (p<0.001). Intraclass correlation coefficients ranged between 0.858 and 0.935. No significant tumor volume differences were observed. Regression analysis demonstrated average ADC as the best predictor of treatment.
Conclusions: Our study suggests that ADC values may be useful for evaluating chemotherapeutic response of malignant pediatric bone tumors.
Keywords: Bone tumor; Chemotherapy response; Ewing sarcoma; Magnetic resonance imaging; Osteosarcoma; Quantitative diffusion-weighted imaging.
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