Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow

Haematologica. 2017 Nov;102(11):e427-e430. doi: 10.3324/haematol.2017.167882. Epub 2017 Aug 17.

Authors

Erica L Clinkenbeard¹, Mark R Hanudel², Keith R Stayrook³, Hitesh Nidumanda Appaiah¹, Emily G Farrow⁴, Taryn A Cass¹, Lelia J Summers¹, Colin S Ip¹, Julia M Hum¹, Joseph C Thomas¹, Mircea Ivan⁵, Briana M Richine⁶, Rebecca J Chan⁶, Thomas L Clemens⁷, Ernestina Schipani⁸, Yves Sabbagh⁹, Linlin Xu¹⁰, Edward F Srour⁶, Marta B Alvarez¹¹, Melissa A Kacena¹¹, Isidro B Salusky², Tomas Ganz¹², Elizabeta Nemeth¹², Kenneth E White¹³

Affiliations

¹ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
² Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
³ Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁴ Center for Pediatric Genomic Medicine at Children's Mercy Hospital, Kansas City, and Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.
⁵ Department of Medicine/Hematology-Oncology, Indiana University School of Medicine, Indianapolis, IN, USA.
⁶ Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
⁷ Department of Orthopaedic Surgery, The Johns Hopkins University and the Baltimore Veterans Administration Medical Center, Baltimore, Maryland, MD, USA.
⁸ Department of Medicine/Endocrinology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
⁹ Rare Diseases, Sanofi Genzyme, Framingham, MA, USA.
¹⁰ Department of Microbiology and Immunology, IUSM, Indianapolis, IN, USA.
¹¹ Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
¹² Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹³ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA [email protected].

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Marrow / metabolism*
Bone Marrow Cells / drug effects
Bone Marrow Cells / metabolism
Bone and Bones / metabolism*
Cells, Cultured
Dose-Response Relationship, Drug
Erythropoietin / pharmacology*
Fibroblast Growth Factor-23
Fibroblast Growth Factors / blood
Fibroblast Growth Factors / genetics*
Gene Expression Profiling
Gene Expression Regulation / drug effects*
Hematopoietic Stem Cells / drug effects
Hematopoietic Stem Cells / metabolism
Humans
Mice

Substances

Erythropoietin
Fibroblast Growth Factors
Fibroblast Growth Factor-23

Grants and funding