Abstract
During October-December 2015, 29 patients in a hospital in the Netherlands acquired nosocomial infection with a multidrug-resistant, New Delhi-metallo-β-lactamase-positive Klebsiella pneumoniae strain. Extensive infection control measures were needed to stop this outbreak. The estimated economic impact of the outbreak was $804,263; highest costs were associated with hospital bed closures.
Keywords:
CPE; ESBL; Enterobacteriaceae; HRMO; Klebsiella pneumoniae; NDM-1; antimicrobial resistance; bacteria; costs; economic; extended-spectrum β-lactamase; nosocomial; outbreak; the Netherlands.
MeSH terms
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Anti-Bacterial Agents / economics
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Anti-Bacterial Agents / therapeutic use
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Carrier State
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Cost of Illness*
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Cross Infection / diagnosis
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Cross Infection / economics*
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Cross Infection / epidemiology
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Cross Infection / microbiology
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Disease Outbreaks / economics*
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Gene Expression
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Hospitals
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Humans
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Incidence
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Klebsiella Infections / diagnosis
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Klebsiella Infections / economics*
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Klebsiella Infections / epidemiology
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Microbial Sensitivity Tests
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Netherlands / epidemiology
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Plasmids / chemistry
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Plasmids / metabolism
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
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beta-Lactams / economics
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beta-Lactams / therapeutic use
Substances
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Anti-Bacterial Agents
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beta-Lactams
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beta-Lactamases
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beta-lactamase NDM-1