Abstract
We have developed a cancer cell specific targeting nanocomplex which combines photodynamic therapy with chemotherapy through precisely responding to the intracellular tumor-related mRNA. The combined treatment of these two modalities showed significantly enhanced therapeutic effects on cancer cells.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / radiation effects
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Chlorophyllides
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DNA / chemistry
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DNA / genetics
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Doxorubicin / chemistry
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Doxorubicin / pharmacology*
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Drug Carriers / chemistry
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Drug Carriers / pharmacology*
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Drug Carriers / radiation effects
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HeLa Cells
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Humans
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Hyaluronic Acid / chemistry
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Hyaluronic Acid / metabolism
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Hyaluronoglucosaminidase / metabolism
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Light
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Mice
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NIH 3T3 Cells
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Nanoparticles / chemistry*
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Nucleic Acid Hybridization
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Particle Size
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Photochemotherapy / methods*
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Porphyrins / chemistry
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Porphyrins / pharmacology
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Porphyrins / radiation effects
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Protamines / chemistry
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RNA, Messenger / genetics
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Radiation-Sensitizing Agents / chemistry
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Radiation-Sensitizing Agents / pharmacology
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Radiation-Sensitizing Agents / radiation effects
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Singlet Oxygen / chemistry
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Thymidine Kinase / genetics
Substances
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Antineoplastic Agents
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Chlorophyllides
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Drug Carriers
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Porphyrins
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Protamines
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RNA, Messenger
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Radiation-Sensitizing Agents
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Singlet Oxygen
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phytochlorin
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Doxorubicin
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Hyaluronic Acid
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DNA
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Thymidine Kinase
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thymidine kinase 1
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Hyaluronoglucosaminidase