Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing, China

Li-Na Guo; Meng Xiao; Bin Cao; Fen Qu; Yu-Liang Zhan; Yun-Jian Hu; Xin-Ru Wang; Guo-Wei Liang; Hai-Tong Gu; Jun Qi; Hui Yuan; Rong Min; Fei-Yan Wang; Lin-Juan Liu; Hai-Bin Wang; Wei Jiang; Xue-Guang Duan; Wen-Jian Xu; Yan-Hua Yu; Jian-Rong Su; Jian-Zhong Zhang; Jin-Qing Nong; Shu-Mei Liu; Jun Li; Jun-Ting Liu; Zhi-Gang Yue; Duo Yang; Jie Guo; Rui Zhao; Ya-Nan Zhang; Xi-Ming Yang; Xiao-Qing Liu; Po-Ren Hsueh; Ying-Chun Xu

doi:10.2217/fmb-2017-0036

Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing, China

Future Microbiol. 2017 Sep:12:1075-1086. doi: 10.2217/fmb-2017-0036. Epub 2017 Aug 24.

Authors

Li-Na Guo¹, Meng Xiao¹, Bin Cao², Fen Qu³, Yu-Liang Zhan⁴, Yun-Jian Hu⁵, Xin-Ru Wang⁶, Guo-Wei Liang⁷, Hai-Tong Gu⁸, Jun Qi⁹, Hui Yuan¹⁰, Rong Min¹¹, Fei-Yan Wang¹², Lin-Juan Liu¹³, Hai-Bin Wang¹⁴, Wei Jiang¹⁵, Xue-Guang Duan¹⁶, Wen-Jian Xu¹⁷, Yan-Hua Yu¹⁸, Jian-Rong Su¹⁹, Jian-Zhong Zhang²⁰, Jin-Qing Nong²¹, Shu-Mei Liu²², Jun Li²³, Jun-Ting Liu²⁴, Zhi-Gang Yue²⁵, Duo Yang²⁶, Jie Guo²⁷, Rui Zhao²⁸, Ya-Nan Zhang²⁹, Xi-Ming Yang³⁰, Xiao-Qing Liu³¹, Po-Ren Hsueh³², Ying-Chun Xu¹

Affiliations

¹ Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
² Department of Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100000, China.
³ Department of Clinical Laboratory, 302 Military Hospital of China, Peking University, Beijing 100039, China.
⁴ Department of Clinical Laboratory, China-Japan Friendship Hospital, Peking University Health Science Center, Beijing University of Chinese Medicine, Beijing 100029, China.
⁵ Department of Clinical Laboratory, Beijing Hospital, Peking University, Beijing 100730, China.
⁶ Department of Clinical Laboratory, The General Hospital of PLA Rocket Force, Beijing 100088, China.
⁷ Department of Clinical Laboratory, Aerospace Center Hospital, Peking University, Beijing 100049, China.
⁸ Department of Clinical Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
⁹ Department of Clinical Laboratory, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
¹⁰ Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung & Blood Vessel Diseases, Beijing 100029, China.
¹¹ Department of Clinical Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
¹² Department of Clinical Laboratory, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China.
¹³ Department of Clinical Laboratory, Peking University Cancer Hospital & Institute, Peking University, Beijing 100142, China.
¹⁴ Department of Clinical Laboratory, First Affiliated Hospital of Chinese PLA General Hospital, The Second Military Medical University, Beijing 100048, China.
¹⁵ Department of Infection Control, First Affiliated Hospital of Chinese PLA General Hospital, The Second Military Medical University, Beijing 100048, China.
¹⁶ Department of Clinical Laboratory, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
¹⁷ Department of Clinical Laboratory, Children's Hospital, Capital institute of Pediatrics, Beijing 100020, China.
¹⁸ Department of Clinical Laboratory, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China.
¹⁹ Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
²⁰ State Key Laboratory of Infectious Disease Prevention & Control, Collaborative Innovation Centre for Diagnosis & Treatment of Infectious Diseases, National Institute for Communicable Disease Control & Prevention, Chinese Center for Disease Control & Prevention, Beijing 102206, China.
²¹ Department of Clinical Laboratory, Shougang Hospital, Peking University, Beijing 100144, China.
²² Department of Clinical Laboratory, FuXing Hospital, Capital Medical University, Beijing 100038, China.
²³ Department of Clinical Laboratory, Second Hospital of Armed Police Beijing Office, Jiangxi University of Traditional Chinese Medicine, Beijing 100037, China.
²⁴ Department of Clinical Laboratory, FengTai Hospital, Capital Medical University, Beijing 100070, China.
²⁵ Department of Clinical Laboratory, China MeiTan General Hospital, North China Coal Medical University, Beijing 100028, China.
²⁶ Department of Clinical Laboratory, Beijing ShiJiTan Hospital, Capital Medical University, Beijing 100038, China.
²⁷ Department of Clinical Laboratory, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
²⁸ Department of Clinical Laboratory, State Grid Corporation of China Beijing Electric Power Hospital, Capital Medical University, Beijing 100073, China.
²⁹ Department of Clinical Laboratory, Beijing TianTan Hospital, Capital Medical University, Beijing 100050, China.
³⁰ Department of Clinical Laboratory, DongZhiMen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
³¹ Department of Infectious Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
³² Departments of Laboratory Medicine & Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei 100, Taiwan.

PMID: 28836465
DOI: 10.2217/fmb-2017-0036

Abstract

Aim: To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing.

Materials & methods: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method.

Results: Candida (95.5%) remained the most common yeast species isolated; Candida albicans (38.8%) and Candida parapsilosis (22.6%) were the leading species of candidemia. Azole resistances were mainly observed in Candida glabrata and Candida tropicalis isolates.

Conclusion: This study outlined the epidemiologic data of invasive yeast infections and highlighted the need for continuous monitoring of azole resistances among C. glabrata and C. tropicalis isolates in Beijing.

Keywords: antifungal susceptibilities; epidemiology; invasive yeast infection.

MeSH terms

Adolescent
Adult
Aged
Amphotericin B / pharmacology
Antifungal Agents
Beijing / epidemiology
Candida / drug effects
Candida / genetics
Candida / isolation & purification
Candida / pathogenicity
Candida albicans / drug effects
Candida albicans / genetics
Candida albicans / isolation & purification
Candida albicans / pathogenicity
Candida glabrata / drug effects
Candida glabrata / genetics
Candida glabrata / isolation & purification
Candida glabrata / pathogenicity
Candida parapsilosis / drug effects
Candida parapsilosis / genetics
Candida parapsilosis / isolation & purification
Candida parapsilosis / pathogenicity
Candida tropicalis / drug effects
Candida tropicalis / genetics
Candida tropicalis / isolation & purification
Candida tropicalis / pathogenicity
Candidemia / epidemiology
Candidemia / microbiology
Candidiasis, Invasive / epidemiology*
Candidiasis, Invasive / microbiology*
Child
Child, Preschool
Drug Resistance, Fungal / drug effects
Echinocandins / pharmacology
Epidemiological Monitoring
Female
Humans
Infant
Infant, Newborn
Male
Microbial Sensitivity Tests / methods*
Middle Aged
Sequence Analysis, DNA
Triazoles / pharmacology
Yeasts / drug effects*
Yeasts / genetics
Yeasts / isolation & purification*
Yeasts / pathogenicity
Young Adult

Substances

Antifungal Agents
Echinocandins
Triazoles
Amphotericin B