Cis- and trans-acting lncRNAs in pluripotency and reprogramming

Pixi Yan; Sai Luo; J Yuyang Lu; Xiaohua Shen

doi:10.1016/j.gde.2017.07.009

Cis- and trans-acting lncRNAs in pluripotency and reprogramming

Curr Opin Genet Dev. 2017 Oct:46:170-178. doi: 10.1016/j.gde.2017.07.009. Epub 2017 Aug 19.

Authors

Pixi Yan¹, Sai Luo¹, J Yuyang Lu¹, Xiaohua Shen²

Affiliations

¹ Department of Basic Medical Sciences, School of Medicine, Center for Life Sciences, Tsinghua University, Beijing 100084, China.
² Department of Basic Medical Sciences, School of Medicine, Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: [email protected].

PMID: 28843809
DOI: 10.1016/j.gde.2017.07.009

Abstract

Pervasive transcription in mammalian genomes produces thousands of long noncoding RNA (lncRNA) transcripts. Although they have been implicated in diverse biological processes, the functional relevance of most lncRNAs remains unknown. Recent studies reveal the prevalence of lncRNA-mediated cis regulation on nearby transcription. In this review, we summarize cis- and trans-acting lncRNAs involved in stem cell pluripotency and reprogramming, highlighting the role of regulatory lncRNAs in providing an additional layer of complexity to the regulation of genes that govern cell fate during development.

Publication types

Review

MeSH terms

Cell Differentiation / genetics*
Computational Biology
Gene Expression Regulation, Developmental / genetics
Gene Regulatory Networks / genetics
Humans
Pluripotent Stem Cells*
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding