In the last years, significant progress has been made in the clinical follow-up of leukemia patients who are especially prone to various infections because of the specific immunosuppressive state following chemotherapy. The follow-up of such patients is of special interest and is based on modern imaging protocols especially computer tomography (CT). Still, CT may not always be effective in the diagnosing of respiratory infections. We report a chronic lymphocytic leukemia patient in which the pleuro-pulmonary complications were successfully diagnosed and followed up using transthoracic ultrasonography.