Chromosome-Mediated mcr-3 Variants in Aeromonas veronii from Chicken Meat

Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01272-17. doi: 10.1128/AAC.01272-17. Print 2017 Nov.

Abstract

Two adjacent colistin resistance gene variants, termed mcr-3.3 and mcr-3-like, were identified in the chromosome of an Aeromonas veronii isolate obtained from retail chicken meat. The variants showed 95.20% and 84.19% nucleotide sequence identity, respectively, to mcr-3 from porcine Escherichia coli Functional cloning indicated that only mcr-3.3 conferred polymyxin resistance in both E. coli and Aeromonas salmonicida The mcr-3.3-mcr-3-like segment was also observed in other Aeromonas species, including A. media, A. caviae, and A. hydrophila.

Keywords: Aeromonas veronii; colistin resistance; mcr-3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aeromonas veronii / drug effects*
  • Aeromonas veronii / genetics*
  • Aeromonas veronii / isolation & purification
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Chickens / microbiology*
  • China
  • Chromosomes, Bacterial
  • Cloning, Molecular
  • Colistin / pharmacology
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics*
  • Food Microbiology
  • Microbial Sensitivity Tests
  • Polymyxins / pharmacology

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Polymyxins
  • Colistin