Plasma Level of hsa-miR-619-5p microRNA Is Associated with Prostatic Cancer Dissemination beyond the Capsule

M Yu Shkurnikov; Yu A Makarova; E N Knyazev; K A Fomicheva; A V Galatenko; K M Nyushko; V V Galatenko; V I Vechorko; B Ya Alekseev

doi:10.1007/s10517-017-3831-x

Plasma Level of hsa-miR-619-5p microRNA Is Associated with Prostatic Cancer Dissemination beyond the Capsule

Bull Exp Biol Med. 2017 Aug;163(4):475-477. doi: 10.1007/s10517-017-3831-x. Epub 2017 Aug 29.

Authors

M Yu Shkurnikov^{1

2}, Yu A Makarova³, E N Knyazev^{3

4}, K A Fomicheva⁴, A V Galatenko³, K M Nyushko⁴, V V Galatenko³, V I Vechorko⁵, B Ya Alekseev⁴

Affiliations

¹ BioClinicum Research Centre, Moscow, Russia. [email protected].
² P. A. Herzen Moscow Oncology Research Institute, Affiliated Branch of National Medical Research Radiology Center, Ministry of Health of Russia, Moscow, Russia. [email protected].
³ BioClinicum Research Centre, Moscow, Russia.
⁴ P. A. Herzen Moscow Oncology Research Institute, Affiliated Branch of National Medical Research Radiology Center, Ministry of Health of Russia, Moscow, Russia.
⁵ Federal Research Institute of Health Organization and Informatics, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 28853076
DOI: 10.1007/s10517-017-3831-x

Abstract

Profiles of circulating microRNA in the plasma of patients with prostate cancer with pathomorphological stages pT2, pT3, and pT4 are analyzed. The level of circulating microRNA hsa-miR-619-5p is elevated in patients with extracapsular spreading of the tumor, increasing significantly from stage pT2 to stage pT4.

Keywords: blood plasma; cancer stage; little invasive diagnosis; microRNA; prostatic cancer.

MeSH terms

Biomarkers, Tumor / blood*
Cisplatin / pharmacology
Docetaxel
Granulocytes / drug effects
Granulocytes / metabolism
Humans
Male
MicroRNAs / blood
MicroRNAs / genetics*
Neutrophils / cytology
Neutrophils / drug effects
Neutrophils / metabolism
Prostatic Neoplasms / blood*
Stem Cells / cytology
Stem Cells / metabolism
Taxoids / pharmacology

Substances

Biomarkers, Tumor
MIRN-619 microRNA, human
MicroRNAs
Taxoids
Docetaxel
Cisplatin