MSH2 deletion with CREBBP and KRAS mutations in pediatric high-hyperdiploid acute lymphoblastic leukemia

Pediatr Int. 2017 Oct;59(10):1103-1105. doi: 10.1111/ped.13365. Epub 2017 Aug 30.

Authors

Jun-Ichi Ueyama¹, Mizuka Miki², Keisuke Okuno¹, Shohei Eto³, Akira Shimada⁴

Affiliations

¹ Department of Pediatrics, Tottori University Faculty of Medicine, Yonago, Tottori, Japan.
² Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan.
³ Department of Pediatrics, Hiroshima University, Hiroshima, Japan.
⁴ Department of Pediatrics/Pediatric Hematology/Oncology, Okayama University Hospital, Okayama, Japan.

PMID: 28856790
DOI: 10.1111/ped.13365

No abstract available

Keywords: CREBBP; KRAS; MSH2; acute lymphoblastic leukemia; relapse.

Publication types

Case Reports

MeSH terms

Abnormal Karyotype*
Base Sequence
CREB-Binding Protein / genetics*
Child, Preschool
Fatal Outcome
Female
Genetic Markers
Humans
MutS Homolog 2 Protein / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Proto-Oncogene Proteins p21(ras) / genetics*
Sequence Deletion*

Substances

Genetic Markers
KRAS protein, human
CREB-Binding Protein
CREBBP protein, human
MSH2 protein, human
MutS Homolog 2 Protein
Proto-Oncogene Proteins p21(ras)