[Study on property of biopharmaceutics classification system of berberine in Huanglian decoction]

Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1192-1197. doi: 10.4268/cjcmm20160706.
[Article in Chinese]

Abstract

The study of single component in the multicomponent environment is one of the basic researches for biopharmaceutics classification system of Chinese materia medica (CMMBCS). That is to say, the classification research shall be based on the respective lift of solubility and permeability in the multicomponent environment, besides solubility and intestinal permeability of the single component. We chose berberine as the main research object to investigate the changes of its solubility and intestinal permeability in Huanglian decoction. Shake-flask and HPLC were used to detect the solubility of berberine in different pH buffer solutions and different concentrations of Huanglian decoction. In situ single-pass intestinal perfusion (SPIP) and intestinal perfusion with venous sampling (IPVS) were carried out to study berberine's intestinal absorption and absorption into blood, respectively.

Keywords: Coptidis Rhizoma; berberine; biopharmaceutics classification system of Chinese materia medica; intestinal permeability; solubility.

MeSH terms

  • Berberine / pharmacokinetics*
  • Biopharmaceutics / classification
  • Drugs, Chinese Herbal / pharmacokinetics*
  • Intestinal Absorption*
  • Permeability

Substances

  • Drugs, Chinese Herbal
  • huanglian
  • Berberine