Aging: rewiring the circadian clock

Nat Struct Mol Biol. 2017 Sep 7;24(9):687-688. doi: 10.1038/nsmb.3461.

Abstract

The robustness of the circadian clock deteriorates with aging. Two new studies show that aging reprograms the circadian transcriptome in a cell-type-dependent manner and that such rewiring can be reversed by caloric restriction.

Publication types

  • News
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / genetics*
  • Animals
  • Caloric Restriction*
  • Circadian Clocks / genetics*
  • Mice
  • Transcriptome