CRISPR: Established Editor of Human Embryos?

Xiao-Jiang Li; Zhuchi Tu; Weili Yang; Shihua Li

doi:10.1016/j.stem.2017.08.007

CRISPR: Established Editor of Human Embryos?

Cell Stem Cell. 2017 Sep 7;21(3):295-296. doi: 10.1016/j.stem.2017.08.007.

Authors

Xiao-Jiang Li¹, Zhuchi Tu², Weili Yang², Shihua Li³

Affiliations

¹ Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: [email protected].
² Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
³ Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: [email protected].

Abstract

Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.

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MeSH terms

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats*
Gene Editing*
Humans
Mosaicism
Mutation

Abstract

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MeSH terms

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