General characterization of the venoms from two species of rattlesnakes and an intergrade population (C. lepidus x aquilus) from Aguascalientes and Zacatecas, Mexico

Eric Rivas; Edgar Neri-Castro; Melisa Bénard-Valle; Arely I Hernánez-Dávila; F Zamudio; Alejandro Alagón

doi:10.1016/j.toxicon.2017.09.002

General characterization of the venoms from two species of rattlesnakes and an intergrade population (C. lepidus x aquilus) from Aguascalientes and Zacatecas, Mexico

Toxicon. 2017 Nov:138:191-195. doi: 10.1016/j.toxicon.2017.09.002. Epub 2017 Sep 8.

Authors

Eric Rivas¹, Edgar Neri-Castro², Melisa Bénard-Valle², Arely I Hernánez-Dávila², F Zamudio², Alejandro Alagón³

Affiliations

¹ Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ciudad Universitaria, Aguascalientes, Aguascalientes, 20131, Mexico.
² Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos, 62210, Mexico.
³ Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos, 62210, Mexico. Electronic address: [email protected].

PMID: 28890171
DOI: 10.1016/j.toxicon.2017.09.002

Abstract

The venoms from two species of rock rattlesnakes and an intergrade population were studied. Differences were noted in SDS-PAGE and RP-HPLC profiles and only the venom from the intergrade population showed low procoagulant activity. Also, a Crotoxin-like neurotoxic PLA₂ was identified in the venom of C. l. klauberi, the most toxic of the analyzed venoms. This is the first report of such a toxin in C. l. klauberi from Aguascalientes, Mexico.

MeSH terms

Animals
Chromatography, High Pressure Liquid
Coagulants
Crotalid Venoms / chemistry*
Crotalid Venoms / toxicity*
Crotalus / classification*
Electrophoresis, Polyacrylamide Gel
Lethal Dose 50
Mexico
Mice
Neurotoxins

Substances

Coagulants
Crotalid Venoms
Neurotoxins