A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

Affiliations

• ¹ Department of Pathology and Molecular Pathology, University and University Hospital Zurich, 8091 Zurich, Switzerland.
• ² Department of Translational Inflammation Research, Institute of Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany.
• ³ Institute of Virology, Technische Universität München, Helmholtz Zentrum München, 85764 Munich, Germany.
• ⁴ Department of Medicine III, Division of GI and Hepatobiliary Oncology, University Hospital RWTH Aachen, 52056 Aachen, Germany.
• ⁵ Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.
• ⁶ Gastroenterology and Hepatology, University Hospital Zurich, 8091 Zurich, Switzerland.
• ⁷ Centre for Cell Death, Cancer, and Inflammation, Department of Cancer Biology, UCL Cancer Institute, University College London, London WC1E 6DD, UK.
• ⁸ Laboratory of Molecular Immunology and Signal Transduction, GIGA-R, University of Liège, 4000 Liège, Belgium.
• ⁹ Institute of Experimental Internal Medicine, Otto von Guericke University, 39120 Magdeburg, Germany.
• ¹⁰ DNA Repair and Maintenance of Genome Stability, Max-Delbruck Center for Molecular Medicine (MDC) Berlin, 13125 Berlin, Germany.
• ¹¹ Functional Genomics Center Zurich, ETH and University Zurich, 8057 Zurich, Switzerland.
• ¹² Department of Biology, Institute of Molecular Health Sciences, ETH, Zurich, Switzerland.
• ¹³ I. Department of Medicine, University Medical Center, Johannes Gutenberg-University, 55122 Mainz, Germany.
• ¹⁴ Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel.
• ¹⁵ Department of Surgery, Technische Universität München, 80333 Munich, Germany.
• ¹⁶ Department of Internal Medicine VIII, University Hospital Tübingen, 72076 Tübingen, Germany; Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany; Translational Gastrointestinal Oncology Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
• ¹⁷ National Center for Tumor Diseases (NCT), 69120 Heidelberg, Germany.
• ¹⁸ Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.
• ¹⁹ Clinic of Visceral and Transplantation Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
• ²⁰ Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland.
• ²¹ Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
• ²² III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany.
• ²³ Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
• ²⁴ Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
• ²⁵ Adult Stem Cell Laboratory, The Francis Crick Institute, London NW1 1AT, UK.
• ²⁶ Department of Pathology and Molecular Pathology, University and University Hospital Zurich, 8091 Zurich, Switzerland; Institute of Virology, Technische Universität München, Helmholtz Zentrum München, 85764 Munich, Germany; Institute of Chronic Inflammation and Cancer, Deutsches Krebs-Forschungszentrum (DKFZ), 69120 Heidelberg, Germany. Electronic address: [email protected].
• ²⁷ Department of Pathology and Molecular Pathology, University and University Hospital Zurich, 8091 Zurich, Switzerland. Electronic address: [email protected].