WIP deficiency severely affects human lymphocyte architecture during migration and synapse assembly

Laurène Pfajfer; Markus G Seidel; Raïssa Houmadi; Javier Rey-Barroso; Tatjana Hirschmugl; Elisabeth Salzer; Inés María Antón; Christian Urban; Wolfgang Schwinger; Kaan Boztug; Loïc Dupré

doi:10.1182/blood-2017-04-777383

WIP deficiency severely affects human lymphocyte architecture during migration and synapse assembly

Blood. 2017 Oct 26;130(17):1949-1953. doi: 10.1182/blood-2017-04-777383. Epub 2017 Sep 13.

Authors

Laurène Pfajfer^{1

2

3

4}, Markus G Seidel⁵, Raïssa Houmadi^{3

4}, Javier Rey-Barroso^{3

4}, Tatjana Hirschmugl^{1

2}, Elisabeth Salzer^{1

2}, Inés María Antón^{6

7}, Christian Urban⁵, Wolfgang Schwinger⁵, Kaan Boztug^{1

2

8

9}, Loïc Dupré^{1

2

3

4}

Affiliations

¹ Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
² CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
³ INSERM, UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.
⁴ Université Toulouse III Paul-Sabatier, Toulouse, France.
⁵ Division of Pediatric Hematology-Oncology, Department of Pediatrics and Adolescent Medicine, Research Unit for Pediatric Hematology and Immunology, Medical University of Graz, Graz, Austria.
⁶ Centro Nacional de Biotecnología, Madrid, Spain.
⁷ Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Madrid, Spain.
⁸ Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; and.
⁹ St. Anna Kinderspital and Children's Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

PMID: 28903942
DOI: 10.1182/blood-2017-04-777383

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Movement
Chemotaxis
Child, Preschool
Cytoskeletal Proteins / deficiency*
Humans
Intracellular Signaling Peptides and Proteins / deficiency*
Lymphocytes / pathology*
Lymphocytes / ultrastructure
Synapses / metabolism

Substances

Cytoskeletal Proteins
Intracellular Signaling Peptides and Proteins
WIPF1 protein, human