To study the chemical constituents of the aerial parts of Myripnois dioica. Twelve compounds were separated from the 95% ethanol extract of M. dioica by using various chromatographic techniques. Their stuctures were identified on the basis of their physicochemical properties and spectral data as 8-desoxyurospermal A(1), zaluzanin C(2), dehydrozaluzanin C(3), glucozaluzanin C(4), macrocliniside B(5), macrocliniside I(6), taraxinic acid-14-O-β-D-glucopyranoside(7), ainsliaside B(8), apigenin(9), luteolin(10), apigenin-7-O-β-D-glucopyranoside(11), and luteolin-7-O-β-D-glucopyranoside(12). Except for compound 8, the other compounds were isolated from this genus for the first time. Compound 8 was found to decrease blood glucose level properly in alloxan-induced diabetic mice.
Keywords: Myripnois dioica; chemical constituents; flavonoids; hypoglycemic activity; sesquiterpenes.
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