Abstract
Eight chlorinated alkylresorcinols, monochasiol A-H (1-8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1-8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Survival / drug effects
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Concanavalin A / pharmacology
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Dictyosteliida / chemistry
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Dictyostelium / chemistry*
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HeLa Cells
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Hexanones / metabolism
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Humans
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Hydrocarbons, Chlorinated* / chemistry
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Hydrocarbons, Chlorinated* / isolation & purification
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Hydrocarbons, Chlorinated* / pharmacology
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Interleukin-2 / biosynthesis
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Jurkat Cells
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyketides / metabolism
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Resorcinols* / chemistry
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Resorcinols* / isolation & purification
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Resorcinols* / pharmacology
Substances
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Hexanones
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Hydrocarbons, Chlorinated
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Interleukin-2
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Polyketides
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Resorcinols
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monochasiol A
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Concanavalin A
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1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone