Effect of a somatostatin analogue, SMS 201-995, on 133Xe clearance from colonic mucosa in unanesthetized man

P E Mortensen; J Olsen; R Bousfield; K Agerskov; J Christiansen

doi:10.3109/00365528708991956

Effect of a somatostatin analogue, SMS 201-995, on 133Xe clearance from colonic mucosa in unanesthetized man

Scand J Gastroenterol. 1987 Nov;22(9):1056-8. doi: 10.3109/00365528708991956.

Authors

P E Mortensen¹, J Olsen, R Bousfield, K Agerskov, J Christiansen

Affiliation

¹ Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.

PMID: 2892248
DOI: 10.3109/00365528708991956

Abstract

The effect of intravenous bolus injection of the somatostatin analogue SMS 201-995 on mucosal and submucosal blood flow was studied with the local 133Xe clearance technique in eight subjects. Mucosal and submucosal blood flow decreased by 33% after injection of SMS 201-995. These observations suggest that SMS 201-995, like somatostatin, inhibits splanchnic blood flow.

MeSH terms

Aged
Colon / blood supply*
Colostomy
Female
Humans
Injections, Intravenous
Intestinal Mucosa / blood supply*
Intestinal Mucosa / drug effects
Male
Middle Aged
Octreotide
Regional Blood Flow / drug effects
Somatostatin / analogs & derivatives*
Somatostatin / pharmacology
Xenon Radioisotopes

Substances

Xenon Radioisotopes
Somatostatin
Octreotide