Establishment of an induced pluripotent stem cell line ZZUi003-A from a 65-year-old male with sporadic Parkinson's disease

Xiangyu Zheng; Zhiqiang Zhu; Kuisheng Chen; Shewei Guo; Tiantian Liu; Hongfang Liu

doi:10.1016/j.scr.2017.07.004

Establishment of an induced pluripotent stem cell line ZZUi003-A from a 65-year-old male with sporadic Parkinson's disease

Stem Cell Res. 2017 Aug:23:119-121. doi: 10.1016/j.scr.2017.07.004. Epub 2017 Jul 15.

Authors

Xiangyu Zheng¹, Zhiqiang Zhu², Kuisheng Chen¹, Shewei Guo³, Tiantian Liu⁴, Hongfang Liu⁵

Affiliations

¹ Department of Pathology, The 1st Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
² Emergency Center, The 1st Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: [email protected].
³ Department of Neurosurgery, The 1st Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
⁴ Department of Neurology, The 1st Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
⁵ Department of Neurology, The 5th Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

PMID: 28925360
DOI: 10.1016/j.scr.2017.07.004

Abstract

Skin fibroblasts were collected from a 65-year-old male patient with sporadic Parkinson's disease. Induced pluripotent stem cells were reprogrammed with human reprogramming factors (KMOSL) using the messenger RNA reprogramming protocol. The transgene-free iPSC line showed pluripotency, displayed normal karyotype, and could form embryoid bodies in vitro and differentiate into all 3 germ layers in vivo. This iPSC line can be a useful cellular model for studying the mechanism of Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cell Line
Humans
Induced Pluripotent Stem Cells / pathology*
Male
Parkinson Disease / pathology*