Developing Neutrophils Must Eat…Themselves!

Zhichao Fan; Klaus Ley

doi:10.1016/j.immuni.2017.08.013

Developing Neutrophils Must Eat…Themselves!

Immunity. 2017 Sep 19;47(3):393-395. doi: 10.1016/j.immuni.2017.08.013.

Authors

Zhichao Fan¹, Klaus Ley²

Affiliations

¹ Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle Drive, La Jolla, CA 92037, USA.
² Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle Drive, La Jolla, CA 92037, USA; Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: [email protected].

PMID: 28930652
DOI: 10.1016/j.immuni.2017.08.013

Abstract

In this issue of Immunity, Riffelmacher et al. (2017) show that autophagy is necessary for the release of free fatty acids from intracellular stores within neutrophil precursor cells. This limits glycolysis, increases oxidative phosphorylation, and is essential for neutrophil maturation.

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MeSH terms

Autophagy*
Humans
Neutrophils / immunology*
Oxidative Phosphorylation