Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease

Nutrients. 2017 Jul 26;9(8):800. doi: 10.3390/nu9080800.

Abstract

Poor dietary composition is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). The majority of NAFLD patients follow diets with overconsumption of simple carbohydrates, total and saturated fat, with reduced intake of dietary fiber and omega-3 rich foods. Although lifestyle modifications including weight loss and exercise remain the keystone of NAFLD management, modifying dietary composition with or without a calorie-restricted diet may also be a feasible and sustainable strategy for NAFLD treatment. In the present review article, we highlight the potential therapeutic role of a "high quality healthy diet" to improve hepatic steatosis and metabolic dysfunction in patients with NAFLD, independent of caloric restriction and weight loss. We provide a literature review evaluating the evidence behind dietary components including fiber-, meat- and omega-3-rich diets and, pending further evidence, we concur with the EASL-EASD-EASO Clinical Guidelines recommendation of the Mediterranean diet as the diet of choice in these patients.

Keywords: Mediterranean diet; dietary composition; non-alcoholic fatty liver disease.

Publication types

  • Review

MeSH terms

  • Diet, Carbohydrate-Restricted
  • Diet, Fat-Restricted
  • Diet, Healthy*
  • Diet, Mediterranean
  • Dietary Approaches To Stop Hypertension
  • Dietary Fiber / administration & dosage
  • Energy Metabolism
  • Fatty Acids, Omega-3 / administration & dosage
  • Feeding Behavior
  • Humans
  • Non-alcoholic Fatty Liver Disease / diagnosis
  • Non-alcoholic Fatty Liver Disease / diet therapy*
  • Non-alcoholic Fatty Liver Disease / embryology
  • Non-alcoholic Fatty Liver Disease / physiopathology
  • Nutritional Status*
  • Nutritive Value
  • Obesity / diagnosis
  • Obesity / diet therapy*
  • Obesity / epidemiology
  • Obesity / physiopathology
  • Probiotics / administration & dosage
  • Recommended Dietary Allowances
  • Risk Reduction Behavior*
  • Treatment Outcome
  • Weight Loss*

Substances

  • Dietary Fiber
  • Fatty Acids, Omega-3