The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

Ye Liu; Bereket Workalemahu; Xingyu Jiang

doi:10.1002/smll.201701815

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo

Small. 2017 Nov;13(43). doi: 10.1002/smll.201701815. Epub 2017 Sep 20.

Authors

Ye Liu¹, Bereket Workalemahu¹, Xingyu Jiang^{1

2}

Affiliations

¹ Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, No. 11 Zhongguancun Beiyitiao, Beijing, 100190, P. R. China.
² Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.

PMID: 28941063
DOI: 10.1002/smll.201701815

Abstract

Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of NMs cellular uptake between in vitro and in vivo, a focus on reviewing recent works about the effects of four physicochemical parameters of NMs (size, rigidity, shape, surface modification) on regulating NMs cellular uptake in vitro and in vivo is undertaken. This review can provide readers some useful clues and new thinking for understanding NMs cellular uptake in depth.

Keywords: cellular uptake; nanomaterials; physicochemical properties.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chemical Phenomena*
Endocytosis*
Humans
Nanostructures / chemistry*
Particle Size
Protein Corona / chemistry
Surface Properties

Substances

Protein Corona