This study describes an optimisation and validation process using liquid chromatography coupled with tandem mass spectrometry to quantify acrylamide in foods mainly consumed by infants and toddlers. A limit of quantification of 5µg.kg-1 for both solid and liquid samples was achieved, except for unprepared infant cereals (LOQ of 18µg.kg-1). The method was then applied to 141 food samples from the first French total diet study on infants and toddlers. Acrylamide was detected in most samples at mean LB/UB concentrations ranging from 0.14 to 102µg.kg-1. The "Follow-on formula" and "Infant formula" products contained the lowest average content (LB/UB of 0.14/2.2µg.kg-1 and 0.60/2.9µg.kg-1 respectively) and the "Sweet and savoury biscuits and bars" (102µg.kg-1; n=1 represented by a plain dry biscuit) contained the highest.
Keywords: Acrylamide; Acrylamide (PubChem CID: 6579); Foods; Infants and toddlers; LC-MS/MS; Method validation; Total diet study.
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