Cryo-EM structure of the extended type VI secretion system sheath-tube complex

Nat Microbiol. 2017 Nov;2(11):1507-1512. doi: 10.1038/s41564-017-0020-7. Epub 2017 Sep 25.

Abstract

The bacterial type VI secretion system (T6SS) uses contraction of a long sheath to quickly thrust a tube with associated effectors across membranes of eukaryotic and bacterial cells 1-5 . Only limited structural information is available about the inherently unstable precontraction state of the T6SS. Here, we obtain a 3.7 Å resolution structure of a non-contractile sheath-tube complex using cryo-electron microscopy and show that it resembles the extended T6SS inside Vibrio cholerae cells. We build a pseudo-atomic model of the complete sheath-tube assembly, which provides a mechanistic understanding of coupling sheath contraction with pushing and rotating the inner tube for efficient target membrane penetration. Our data further show that sheath contraction exposes a buried recognition domain to specifically trigger the disassembly and recycling of the T6SS sheath by the cognate ATP-dependent unfoldase ClpV.

MeSH terms

  • Bacterial Proteins / chemistry
  • Cryoelectron Microscopy
  • Models, Molecular
  • Spheroplasts / ultrastructure
  • Type VI Secretion Systems / chemistry*
  • Type VI Secretion Systems / metabolism
  • Type VI Secretion Systems / ultrastructure*
  • Vibrio cholerae / chemistry*
  • Vibrio cholerae / ultrastructure*

Substances

  • Bacterial Proteins
  • Type VI Secretion Systems