The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation

Xin-Ying Tang; Wen-Bin Zou; Emmanuelle Masson; Liang-Hao Hu; Claude Ferec; Jian-Min Chen; Zhao-Shen Li; Zhuan Liao

doi:10.1136/gutjnl-2017-315180

The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation

Gut. 2018 Jul;67(7):1368-1369. doi: 10.1136/gutjnl-2017-315180. Epub 2017 Sep 26.

Authors

Xin-Ying Tang^#^{1

2}, Wen-Bin Zou^#^{1

2}, Emmanuelle Masson^{3

4}, Liang-Hao Hu^{1

2}, Claude Ferec^{3

4

5

6}, Jian-Min Chen^{3

4

6}, Zhao-Shen Li^{1

2}, Zhuan Liao^{1

2}

Affiliations

¹ Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, the Second Military Medical University, Shanghai, China.
² Shanghai Institute of Pancreatic Diseases, Shanghai, China.
³ Institut National de la Santé et de la Recherche Médicale (INSERM), U1078, Brest, France.
⁴ Laboratoire de Génétique Moléculaire et d'Histocompatibilité, Centre Hospitalier Universitaire (CHU) Brest, Hôpital Morvan, Brest, France.
⁵ Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale (UBO), Brest, France.
⁶ Etablissement Français du Sang (EFS) - Bretagne, Brest, France.

^# Contributed equally.

PMID: 28951524
DOI: 10.1136/gutjnl-2017-315180

No abstract available

Keywords: CTRB1-CTRB2 locus; allele fixation; chronic pancreatitis; genetic risk factor; inversion variant.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Alleles*
Asian People
Gene Frequency
Genetic Variation
Genotype
Humans
Pancreatitis, Chronic / genetics*
Polymorphism, Single Nucleotide
White People