Abstract
In this study, we designed NO-activatable gold nanoparticles (NAM-AuNPs) for specific targeting and photo-thermal ablation of macrophages. The gold nanoparticles showed aggregation behavior in response to NO solution as well as endogenous NO secreted from activated macrophages. Following NIR irradiation, significant cytotoxicity was observed in activated RAW 264.7 cells treated with NAM-AuNPs.
MeSH terms
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Animals
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Gold / chemistry
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Gold / pharmacology*
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects*
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Metal Nanoparticles / chemistry*
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Mice
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Molecular Structure
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NIH 3T3 Cells
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Nitric Oxide / biosynthesis
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Nitric Oxide / chemistry
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Nitric Oxide / pharmacology*
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Particle Size
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Phototherapy
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RAW 264.7 Cells
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Structure-Activity Relationship
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Temperature*
Substances
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Lipopolysaccharides
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Nitric Oxide
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Gold