Use of Rapamycin in a Patient With Juvenile Myelomonocytic Leukemia: A Case Report

Shivani Y Upadhyay; Satiro N De Oliveira; Theodore B Moore

doi:10.1177/2324709617728528

Use of Rapamycin in a Patient With Juvenile Myelomonocytic Leukemia: A Case Report

J Investig Med High Impact Case Rep. 2017 Sep 8;5(3):2324709617728528. doi: 10.1177/2324709617728528. eCollection 2017 Jul-Sep.

Authors

Shivani Y Upadhyay^{1

2}, Satiro N De Oliveira¹, Theodore B Moore¹

Affiliations

¹ University of California, Los Angeles, CA, USA.
² Cedars Sinai Medical Center, Los Angeles, CA, USA.

Abstract

The relapse rate for children with juvenile myelomonocytic leukemia (JMML) status post hematopoietic stem cell transplantation (HSCT) approaches 50% within 5 years. Graft-versus-leukemia (GVL) is thought to play important role in the treatment of JMML. For this reason, careful management of immunosuppressive drugs after HSCT is crucial. This case report demonstrates that rapamycin and GVL represent a viable medical strategy for the management of pediatric patients with JMML who relapse following status post-HSCT.

Keywords: JMML; graft-versus-host disease; rapamycin; transplantation.

Abstract

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