X-linked cleft palate: the gene is localized between polymorphic DNA markers DXYS12 and DXS17

A Ivens; G E Moore; J Chambers; A Arnason; O Jensson; A Bjornsson; R Williamson

doi:10.1007/BF00291735

X-linked cleft palate: the gene is localized between polymorphic DNA markers DXYS12 and DXS17

Hum Genet. 1988 Apr;78(4):356-8. doi: 10.1007/BF00291735.

Authors

A Ivens¹, G E Moore, J Chambers, A Arnason, O Jensson, A Bjornsson, R Williamson

Affiliation

¹ Biochemistry Department, St. Mary's Hospital Medical School, London, UK.

PMID: 2896158
DOI: 10.1007/BF00291735

Abstract

The gene involved in an X-linked form of cleft palate has been finely mapped using 14 restriction fragment length polymorphic (RFLP) markers that cover the long arm of the X chromosome. By the combination of deletion mapping and linkage analysis, the gene has been localized between the anonymous DNA markers DXYS12 on the proximal side, and DXS17 distally.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping
Cleft Palate / genetics*
Female
Genetic Markers*
Humans
Male
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length*
Recombination, Genetic
X Chromosome* / ultrastructure

Substances

Genetic Markers