A Tale of Two Elabela Null Mice

Irinna Papangeli; Hyung J Chun

doi:10.1016/j.tem.2017.09.004

A Tale of Two Elabela Null Mice

Trends Endocrinol Metab. 2017 Nov;28(11):759-760. doi: 10.1016/j.tem.2017.09.004. Epub 2017 Sep 27.

Authors

Irinna Papangeli¹, Hyung J Chun²

Affiliations

¹ Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA.
² Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: [email protected].

Abstract

Elabela (ELA), the second peptide ligand for the apelin receptor, APLNR, was previously found in lower vertebrates to be crucial for endoderm and cardiac development. Two new studies report on the phenotypes of Ela null mice, ranging from defective embryogenesis to preeclampsia, providing new insights and raising greater intrigue on this cardiometabolic pathway.

Keywords: APLNR signaling; GPCR; embryo development; preeclampsia.

Publication types

Comment

MeSH terms

Animals
Apelin Receptors
Female
Humans
Mice
Mice, Knockout
Penetrance*
Peptide Hormones / genetics
Pre-Eclampsia*
Pregnancy

Substances

APLNR protein, human
Apelin Receptors
Peptide Hormones

Grants and funding

R01 HL113005/HL/NHLBI NIH HHS/United States