Abstract
We compared the adherence of E. histolytica trophozoites with a panel of lectin-resistant CHO mutants with altered glycosylation patterns. Our results coupled with data from saccharide inhibition studies indicate that terminal N-acetyllactosamine units on Asn-linked complex type oligosaccharides provide the major determinants on the cellular receptor for E. histolytica adhesion.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbohydrate Sequence
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Cell Adhesion
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Cell Line
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Cell Membrane / metabolism
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Cricetinae
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Cricetulus
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Drug Resistance
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Entamoeba histolytica / physiology*
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Female
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Fibroblasts / cytology*
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Fibroblasts / drug effects
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Fibroblasts / metabolism
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Glycosylation
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Molecular Sequence Data
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Oligosaccharides / physiology
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Ovary / cytology
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Wheat Germ Agglutinins / pharmacology
Substances
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Oligosaccharides
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Wheat Germ Agglutinins