PET-positive bone lesion due to Langerhans cell histiocytosis after BEACOPP therapy for Hodgkin lymphoma: how anamnesis, histopathological accuracy, and molecular analysis could resolve a clinical dilemma

Ann Hematol. 2018 Feb;97(2):355-357. doi: 10.1007/s00277-017-3145-0. Epub 2017 Oct 3.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor
  • Bleomycin / administration & dosage
  • Bleomycin / adverse effects
  • Bone Marrow / pathology
  • Causality
  • Cyclophosphamide / administration & dosage
  • Cyclophosphamide / adverse effects
  • Doxorubicin / administration & dosage
  • Doxorubicin / adverse effects
  • Etoposide / administration & dosage
  • Etoposide / adverse effects
  • Female
  • Hematopoietic Stem Cells / pathology
  • Histiocytosis, Langerhans-Cell / chemically induced*
  • Histiocytosis, Langerhans-Cell / diagnostic imaging
  • Hodgkin Disease / complications
  • Hodgkin Disease / drug therapy*
  • Humans
  • Langerhans Cells / pathology
  • Laser Capture Microdissection
  • Middle Aged
  • Neoplasm Proteins / genetics
  • Point Mutation
  • Positron-Emission Tomography*
  • Prednisone / administration & dosage
  • Prednisone / adverse effects
  • Procarbazine / administration & dosage
  • Procarbazine / adverse effects
  • Proto-Oncogene Proteins B-raf / genetics
  • Reed-Sternberg Cells / pathology
  • Temporal Bone / diagnostic imaging*
  • Vincristine / administration & dosage
  • Vincristine / adverse effects

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Bleomycin
  • Procarbazine
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf
  • Prednisone

Supplementary concepts

  • BEACOPP protocol