Binding of acarbose, an anti-diabetic drug to lysozyme: a combined structural and thermodynamic study

J Biomol Struct Dyn. 2018 Oct;36(13):3354-3361. doi: 10.1080/07391102.2017.1388283. Epub 2017 Oct 20.

Authors

K V Dileep¹, K Nithiyanandan¹, C Remya²

Affiliations

¹ a School of Chemistry , Indian Institute of Science Education and Research , Thiruvananthapuram, Sreekaryam , Kerala , India.
² b Department of Biotechnology and Microbiology , Kannur University , Kannur , Kerala , India.

PMID: 28984494
DOI: 10.1080/07391102.2017.1388283

No abstract available

Keywords: acarbose; hereditary systemic amyloidosis; lysozyme aggregation; molecular docking; molecular dynamics and ITC.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acarbose / chemistry*
Acarbose / pharmacology*
Amyloidosis / drug therapy*
Circular Dichroism
Drug Repositioning*
Glycoside Hydrolase Inhibitors / chemistry*
Humans
Molecular Docking Simulation
Molecular Structure
Muramidase / chemistry*
Protein Binding
Thermodynamics

Substances

Glycoside Hydrolase Inhibitors
Muramidase
Acarbose