Gut with the Program: Direct Reprogramming toward Intestinal Epithelium Realized

Angela Nakauka-Ddamba; Christopher J Lengner

doi:10.1016/j.stem.2017.09.011

Gut with the Program: Direct Reprogramming toward Intestinal Epithelium Realized

Cell Stem Cell. 2017 Oct 5;21(4):417-418. doi: 10.1016/j.stem.2017.09.011.

Authors

Angela Nakauka-Ddamba¹, Christopher J Lengner²

Affiliations

¹ Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: [email protected].

PMID: 28985520
DOI: 10.1016/j.stem.2017.09.011

Abstract

Intestinal organoids offer great promise for modeling intestinal diseases; however, harvesting intestinal tissue is invasive and directed hPSC differentiation protocols are laborious and costly. In this issue of Cell Stem Cell, Miura and Suzuki (2017) describe the direct conversion of somatic cells from both mice and humans into robust intestinal epithelial tissue.

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MeSH terms

Animals
Cell Differentiation
Humans
Intestinal Mucosa / cytology*
Intestines / cytology
Mice
Organoids / cytology*
Stem Cells / cytology