Enantioselective Rhodium-Catalyzed Alkenylation of Aliphatic Imines

Org Lett. 2017 Oct 20;19(20):5601-5604. doi: 10.1021/acs.orglett.7b02737. Epub 2017 Oct 9.

Abstract

An efficient, enantioselective rhodium-catalyzed addition of potassium alkenyltrifluoroborates to N-nosyl aliphatic imines has been realized. Good reaction yields and excellent enantioselectivities (94-99% ee) were obtained for a variety of aliphatic imines and nucleophilic alkenyltrifluoroborates. An active rhodium-diene catalyst and the precise reaction condition control proved to be pivotal for success.

Publication types

  • Research Support, Non-U.S. Gov't