Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

Philip C Hogan; Chi-Li Chen; Kristen M Mulvihill; Jonathan F Lawrence; Eric Moorhead; Jens Rickmeier; Andrew G Myers

doi:10.1038/ja.2017.116

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

J Antibiot (Tokyo). 2018 Feb;71(2):318-325. doi: 10.1038/ja.2017.116. Epub 2017 Oct 11.

Authors

Philip C Hogan¹, Chi-Li Chen¹, Kristen M Mulvihill¹, Jonathan F Lawrence¹, Eric Moorhead¹, Jens Rickmeier², Andrew G Myers²

Affiliations

¹ Process Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA.
² Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

PMID: 29018266
DOI: 10.1038/ja.2017.116

Abstract

Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Drug Discovery
Drug Industry
Indicators and Reagents
Macrolides / chemical synthesis*
Protein Synthesis Inhibitors / chemical synthesis

Substances

Anti-Bacterial Agents
Indicators and Reagents
Macrolides
Protein Synthesis Inhibitors