Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection Reduces Recurrent Urinary Tract Infection Frequency

Clin Infect Dis. 2017 Oct 30;65(10):1745-1747. doi: 10.1093/cid/cix618.

Abstract

Broad-spectrum antibiotics for recurrent multidrug-resistant urinary tract infections (UTIs) disrupt the gut microbiome and promote antibiotic resistance. Fecal microbiota transplantation led to resolution of recurrent Clostridium difficile, significantly decreased recurrent UTI frequency, and improved antibiotic susceptibility profile of UTI-causing organisms.

Keywords: C. difficile infection; fecal transplant; infection; microbiome; urinary tract infections.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Clostridioides difficile / drug effects
  • Clostridium Infections / complications
  • Clostridium Infections / drug therapy
  • Clostridium Infections / epidemiology*
  • Clostridium Infections / therapy*
  • Fecal Microbiota Transplantation*
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Recurrence
  • Retrospective Studies
  • Urinary Tract Infections / complications*
  • Urinary Tract Infections / epidemiology*

Substances

  • Anti-Bacterial Agents